Personalized prescription hormone medicines(HRT) delivered to your door
For menopausal women ages from 40 and above
ED truck
cartStarting at $35/Month
cart90 day supply at a time
cartFast shipping
Requesting a prescription only
takes a few minutes.
your meds
Answer health questions
Doctor review
Get meds delivered to your door

Don't use Hot Flashes if any
of the following apply
  • under age 40
  • breastfeeding
  • pregnant
  • had a period in the last 12 months
    ( this means you're not technically menopausal)
dashed line
What are Hot Flashes?

Hot flashes are short episodes of intense heat sensation of the head, neck, and chest. When it occurs with a red face, neck, and/or chest it is called a hot flush. Some women experience sweating and/or palpitations (a sense of the heart beating irregularly) during these episodes. They can occur at any time without warning and usually last 3–5 minutes. However, they can vary from 30 seconds to 30 minutes. Some women have hot flashes/flushes up to 20X/day or more. Hot flashes/flushes can disturb sleep and can be awkward when they occur inexplicably in social situations.

The most common symptom of menopause and perimenopause is hot flashes/flushes, which are estimated to occur in up to 80% of women. Bothersome hot flashes can occur day or night. Nighttime hot flashes often cause night sweats and can interrupt a woman’s sleep.

What causes hot flashes?

The cause of hot flashes/flushes is not completely understood. It is believed that the hypothalamus, a part of the brain involved in temperature regulation, undergoes changes that make it more sensitive to minor increases in body temperature. It inappropriately sends out signals telling the body to rid itself of body heat even when it should not. Blood vessels in the skin swell trying to discharge body heat. This causes redness (flushing) and a sense of warmth. The heart rate can increase leading to palpitations, and sweating can be pronounced as the body tries to cool itself.

Declining estrogen levels play a role in the disrupted temperature regulation by the hypothalamus. This is why symptoms occur around menopause and why estrogen is an effective therapy.

Brain chemicals called neurotransmitters also play a role. In particular serotonin, norepinephrine, and endorphins are thought to be involved in the generation of hot flashes/flushes. Nonhormonal treatment modalities may help by modulating these systems of neurotransmitters.


Signs and symptoms vary, depending on whether this is your first outbreak or a recurrence. They can last several days, and the blisters can take two to four weeks to heal completely. Recurrences typically appear at the same spot each time and tend to be less severe than the first outbreak.


Paroxetine, Venlafaxine

Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) are drug families most commonly used to treat anxiety and depression. Nevertheless, in low doses they have proven effective in the treatment of hot flashes.

Several SSRIs and SNRIs have been found effective for the treatment of hot flashes. One study showed that the SNRI venlafaxine (at 75 mg/day) and low dose estrogen (0.5 mg of beta-estradiol/day) were equally effective at reducing hot flash frequency at 8 weeks (47.6% in the venlafaxine group vs 52.9% in the estradiol group). Learn more about venlafaxine here.

The North American Menopause Society (NAMS) recommends using paroxetine in doses of 10 mg – 25 mg per day as an affordable option for treating hot flashes. Learn more about paroxetine here.

The use of paroxetine and venlafaxine for the treatment of hot flashes is an “off-label” use. ILiveActive-affiliated physicians have the discretion to prescribe these drugs off-label to meet the needs of individual patients. It is up to the medical judgment of the doctor to decide if such treatment is appropriate based on each patient’s unique medical history, symptoms, and preferences.

While venlafaxine and paroxetine are taken in low does for the treatment of hot flashes, any medication can have side effects. These drugs may not be appropriate for everyone. For more about the safety of venlafaxine and paroxetine, including the boxed warning for increased suicidal thoughts in people under 25, please read paroxetine important safety information and venlafaxine important safety information.

Vitamin E & Black Cohosh

Vitamin E is an essential nutrient needed for healthy vision, reproduction, and immunity. It is a fat-soluble vitamin that is also an antioxidant. Black Cohosh is a plant whose roots are used as an herbal supplement. Both have been found in several studies to be effective in the treatment of hot flashes.

It's important to understand the Hot Flashes
treatment we prescribe and potential risks.

Our doctors prescribe 2 separate medicines for hot flashes: Paroxetine HCL and Venlafaxine HCL which starts from $35.00 Learn more

Important safety information

Over the counter Vitamin E and Black Cohosh Learn more

Great care you can afford

Download the app. It's FREE!

phone curve
Do you want your products at your door step?
Your cart is empty
Please Enter Coupon code
Please Login to apply coupon